Journal: Vaccines
Article Title: Differences in Responses of Immunosuppressed Kidney Transplant Patients to Moderna mRNA-1273 versus Pfizer-BioNTech
doi: 10.3390/vaccines12010091
Figure Lengend Snippet: Balance of Th1 and Tr1 response affects the anti-SARS-CoV-2 IgG titer after vaccination. ( A ), KT recipients vaccinated with the mRNA-1273 (squares) produced less spots than PBMCs from KT recipients vaccinated with the Pfizer-BioNTech vaccine (triangles). Correlation between serum IgG levels was shown in KT recipients with IL-10 spots ( B ) and TNF-α spots in ELISpot assay ( C ). Correlation between the ratio of TNF-α to IL-10 spots shown ( D ).
Article Snippet: Overall, Moderna benefited from Th1 response in KT recipients as the average fT IL-2 (11.3/5 × 104) was 19-fold higher than that of Pfizer-BioNTech (0.6/5 × 10 4 , p = 0.009, D).
Techniques: Produced, Enzyme-linked Immunospot